Pinealon: Research Profile and Protocol Guide

Overview

Pinealon is a synthetic tripeptide bioregulator (Glu-Asp-Arg) developed by Professor Vladimir Khavinson's research group, designed to target brain and central nervous system tissue. It belongs to the same family of short peptide bioregulators as Epithalon (pineal gland), Cartalax (cartilage), and other tissue-specific peptides studied at the Saint Petersburg Institute of Bioregulation and Gerontology. Pinealon is specifically researched for neuroprotective effects, cognitive function support, and brain tissue maintenance during aging. In vitro and animal studies from the Khavinson group have demonstrated Pinealon's ability to protect neurons from hypoxic damage, reduce oxidative stress in brain tissue, and modulate gene expression patterns associated with neuroprotection and cognitive function.

Mechanism of Action

Pinealon is theorized to interact with DNA in brain tissue cells, modulating expression of genes involved in neuronal survival, synaptic plasticity, and neuroprotection. Research has demonstrated the peptide can cross model cell membranes and reach the nucleus, where it may influence transcription of genes related to antioxidant defense, anti-apoptotic signaling, and neurotransmitter metabolism. Studies have shown Pinealon reduces markers of oxidative damage in neuronal cell cultures exposed to hypoxia and toxic insults, suggesting a protective role in brain tissue maintenance. The peptide has also been studied for its effects on serotonin and melatonin metabolism, consistent with its name referencing pineal gland function.

Research Applications

Neuroprotection and cognitive aging research, brain tissue maintenance during aging, hypoxia protection studies, neurodegenerative disease research, sleep and circadian rhythm support, bioregulator peptide mechanism studies

Research Protocols

Safety Profile and Considerations

Short peptide with favorable safety profile in published Russian research. No significant adverse effects reported. No Western clinical trials or FDA approval. Used in Russian anti-aging and neuroprotection protocols. Minimal pharmacokinetic data available outside Russian literature.

Storage and Stability

Lyophilized: -20C. Stable at room temperature as capsule formulation. See our storage and handling guide for comprehensive best practices.

Published Research

• Khavinson VK, et al. Neuroprotective effects of short peptides. Bull Exp Biol Med. 2008
  PMID: 19110580

Search for additional Pinealon research on PubMed.

Where to Source Pinealon

Peptide purity is critical for research accuracy. We evaluate suppliers against our 100-point methodology.