/* ============================================================
   DESIGN TOKENS
   ============================================================ */
:root {
  --color-primary: #1B3A5C;
  --color-primary-light: #2D5F8A;
  --color-primary-dark: #0F2640;
  --color-accent: #0D9488;
  --color-accent-light: #5EEAD4;
  --color-accent-dark: #0A7A70;
  --color-surface: #F8FAFB;
  --color-surface-alt: #EEF2F5;
  --color-text-primary: #1A1A2E;
  --color-text-secondary: #6B7280;
  --color-border: #D1D5DB;
  --color-warning: #F59E0B;
  --color-warning-light: #FEF3C7;
  --color-danger: #DC2626;
  --color-supplier-gold: #D4A843;
  --color-supplier-gold-light: #FDF8EC;
  --color-white: #FFFFFF;
  --color-success: #059669;
  --color-success-light: #D1FAE5;

  --font-heading: 'Inter', -apple-system, BlinkMacSystemFont, sans-serif;
  --font-body: 'Inter', -apple-system, BlinkMacSystemFont, sans-serif;
  --font-mono: 'JetBrains Mono', 'Fira Code', monospace;

  --nav-height: 72px;
  --max-width: 1240px;
  --radius-sm: 6px;
  --radius-md: 10px;
  --radius-lg: 16px;
  --shadow-sm: 0 1px 3px rgba(27,58,92,0.06), 0 1px 2px rgba(27,58,92,0.04);
  --shadow-md: 0 4px 12px rgba(27,58,92,0.08), 0 2px 4px rgba(27,58,92,0.04);
  --shadow-lg: 0 12px 32px rgba(27,58,92,0.10), 0 4px 8px rgba(27,58,92,0.06);
  --shadow-gold: 0 4px 20px rgba(212,168,67,0.15), 0 2px 6px rgba(212,168,67,0.10);
}

/* RESET + BASE */
*, *::before, *::after { margin: 0; padding: 0; box-sizing: border-box; }
html { scroll-behavior: smooth; -webkit-font-smoothing: antialiased; }
body { font-family: var(--font-body); font-size: 17px; line-height: 1.7; color: var(--color-text-primary); background: var(--color-surface); }
a { color: var(--color-primary-light); text-decoration: none; transition: color 0.2s; }
a:hover { color: var(--color-accent); }
h1, h2, h3, h4 { font-family: var(--font-heading); line-height: 1.3; }
.container { max-width: var(--max-width); margin: 0 auto; padding: 0 24px; }

/* ============================================================
   NAVIGATION
   ============================================================ */
.prg-nav { position: sticky; top: 0; z-index: 1000; height: var(--nav-height); background: rgba(255,255,255,0.95); border-bottom: 1px solid var(--color-border); backdrop-filter: blur(12px); }
.prg-nav .container { display: flex; align-items: center; justify-content: space-between; height: 100%; }
.prg-nav-logo { display: flex; align-items: center; gap: 10px; font-weight: 800; font-size: 18px; color: var(--color-primary); letter-spacing: -0.02em; text-decoration: none; }
.prg-nav-logo:hover { color: var(--color-primary); }
.prg-nav-links { display: flex; align-items: center; gap: 6px; list-style: none; }
.prg-nav-links a { display: block; padding: 8px 14px; font-size: 15px; font-weight: 500; color: var(--color-text-primary); border-radius: var(--radius-sm); transition: background 0.2s, color 0.2s; }
.prg-nav-links a:hover { background: var(--color-surface-alt); color: var(--color-accent); }
.prg-nav-links a.active { color: var(--color-accent); background: rgba(13,148,136,0.06); }
.prg-nav-cta { background: var(--color-accent) !important; color: var(--color-white) !important; font-weight: 600 !important; }
.prg-nav-cta:hover { background: var(--color-accent-dark) !important; }
.prg-nav-toggle { display: none; background: none; border: none; cursor: pointer; padding: 8px; }

/* ============================================================
   PAGE HEADER
   ============================================================ */
.prg-page-header { background: linear-gradient(145deg, var(--color-primary-dark), var(--color-primary)); padding: 44px 0 48px; position: relative; overflow: hidden; }
.prg-page-header::after { content: ''; position: absolute; inset: 0; background-image: radial-gradient(circle, rgba(94,234,212,0.08) 1px, transparent 1px); background-size: 32px 32px; pointer-events: none; }
.prg-page-header .container { position: relative; z-index: 2; }
.prg-breadcrumbs { display: flex; align-items: center; gap: 8px; font-size: 14px; color: rgba(255,255,255,0.5); margin-bottom: 14px; flex-wrap: wrap; }
.prg-breadcrumbs a { color: rgba(255,255,255,0.6); }
.prg-breadcrumbs a:hover { color: var(--color-accent-light); }
.prg-breadcrumbs svg { opacity: 0.4; }
.prg-page-header h1 { font-size: 38px; font-weight: 800; color: var(--color-white); letter-spacing: -0.03em; margin-bottom: 12px; max-width: 700px; }
.prg-header-meta { display: flex; align-items: center; gap: 16px; flex-wrap: wrap; }
.prg-header-tag { display: inline-flex; align-items: center; gap: 5px; padding: 4px 12px; background: rgba(13,148,136,0.15); border-radius: 6px; font-size: 12px; font-weight: 600; color: var(--color-accent-light); text-transform: uppercase; letter-spacing: 0.05em; }
.prg-header-stat { font-size: 13px; color: rgba(255,255,255,0.55); }
.prg-header-stat strong { color: rgba(255,255,255,0.8); font-weight: 600; }

/* ============================================================
   CONTENT LAYOUT: TOC + MAIN + SIDEBAR
   ============================================================ */
.profile-layout { display: grid; grid-template-columns: 220px 1fr 300px; gap: 36px; padding: 48px 0 80px; align-items: flex-start; }

/* TABLE OF CONTENTS */
.profile-toc { position: sticky; top: calc(var(--nav-height) + 24px); }
.profile-toc h4 { font-size: 11px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.1em; color: var(--color-text-secondary); margin-bottom: 14px; }
.profile-toc-list { list-style: none; }
.profile-toc-list li { margin-bottom: 2px; }
.profile-toc-list a { display: block; padding: 6px 12px; font-size: 13px; font-weight: 500; color: var(--color-text-secondary); border-left: 2px solid transparent; border-radius: 0 4px 4px 0; transition: all 0.2s; line-height: 1.4; }
.profile-toc-list a:hover { color: var(--color-accent); background: rgba(13,148,136,0.04); }
.profile-toc-list a.active { color: var(--color-accent); border-left-color: var(--color-accent); background: rgba(13,148,136,0.06); font-weight: 600; }

/* MAIN CONTENT */
.profile-main { min-width: 0; }

/* Research disclaimer */
.prg-disclaimer-box { display: flex; gap: 14px; padding: 16px 20px; background: var(--color-warning-light); border: 1px solid rgba(245,158,11,0.3); border-radius: var(--radius-md); margin-bottom: 36px; font-size: 14px; line-height: 1.55; color: #92400E; }
.prg-disclaimer-box svg { flex-shrink: 0; margin-top: 2px; }

/* Quick facts card */
.quick-facts { background: var(--color-white); border: 1px solid var(--color-border); border-radius: var(--radius-lg); padding: 28px; margin-bottom: 40px; }
.quick-facts h3 { font-size: 16px; font-weight: 700; margin-bottom: 16px; display: flex; align-items: center; gap: 8px; }
.quick-facts h3 svg { color: var(--color-accent); }
.qf-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 0; }
.qf-item { padding: 10px 0; border-bottom: 1px solid var(--color-surface-alt); }
.qf-item:nth-child(odd) { padding-right: 16px; border-right: 1px solid var(--color-surface-alt); }
.qf-item:nth-child(even) { padding-left: 16px; }
.qf-item:nth-last-child(-n+2) { border-bottom: none; }
.qf-label { font-size: 12px; font-weight: 600; text-transform: uppercase; letter-spacing: 0.06em; color: var(--color-text-secondary); margin-bottom: 2px; }
.qf-value { font-size: 15px; font-weight: 500; color: var(--color-text-primary); }
.qf-value.mono { font-family: var(--font-mono); font-size: 13px; word-break: break-all; }

/* Section styling */
.profile-section { margin-bottom: 48px; scroll-margin-top: calc(var(--nav-height) + 24px); }
.profile-section h2 { font-size: 26px; font-weight: 700; margin-bottom: 16px; padding-bottom: 12px; border-bottom: 2px solid var(--color-surface-alt); color: var(--color-text-primary); }
.profile-section h3 { font-size: 20px; font-weight: 600; margin: 24px 0 12px; color: var(--color-text-primary); }
.profile-section p { margin-bottom: 14px; }
.profile-section p:last-child { margin-bottom: 0; }

/* Citations inline */
.cite { font-size: 12px; font-weight: 600; color: var(--color-accent); vertical-align: super; line-height: 0; cursor: pointer; text-decoration: none; }
.cite:hover { color: var(--color-accent-dark); text-decoration: underline; }

/* Evidence tags */
.evidence-tag { display: inline-flex; align-items: center; gap: 4px; padding: 3px 10px; font-size: 11px; font-weight: 600; text-transform: uppercase; letter-spacing: 0.04em; border-radius: 4px; }
.evidence-tag.animal { background: #EDE9FE; color: #6D28D9; }
.evidence-tag.invitro { background: #E0F2FE; color: #0369A1; }
.evidence-tag.clinical { background: var(--color-success-light); color: var(--color-success); }
.evidence-tag.fda { background: #D1FAE5; color: #047857; }

/* Application list */
.app-list { list-style: none; margin: 16px 0; }
.app-item { display: flex; gap: 14px; padding: 14px 0; border-bottom: 1px solid var(--color-surface-alt); align-items: flex-start; }
.app-item:last-child { border-bottom: none; }
.app-item-content { flex: 1; }
.app-item-content strong { font-weight: 600; display: block; margin-bottom: 2px; }
.app-item-content p { font-size: 15px; color: var(--color-text-secondary); margin: 0; line-height: 1.55; }

/* Protocol box */
.protocol-box { background: var(--color-surface-alt); border-radius: var(--radius-md); padding: 24px; margin: 20px 0; }
.protocol-box h4 { font-size: 15px; font-weight: 700; margin-bottom: 12px; display: flex; align-items: center; gap: 8px; }
.protocol-box h4 svg { color: var(--color-accent); }
.protocol-row { display: flex; justify-content: space-between; padding: 8px 0; border-bottom: 1px solid var(--color-border); font-size: 15px; }
.protocol-row:last-child { border-bottom: none; }
.protocol-row span:first-child { color: var(--color-text-secondary); font-weight: 500; }
.protocol-row span:last-child { font-family: var(--font-mono); font-weight: 600; color: var(--color-text-primary); font-size: 14px; }

/* Disclaimer inline */
.inline-disclaimer { display: flex; gap: 10px; padding: 14px 18px; background: var(--color-surface-alt); border-left: 3px solid var(--color-warning); border-radius: 0 var(--radius-sm) var(--radius-sm) 0; margin: 20px 0; font-size: 14px; color: var(--color-text-secondary); line-height: 1.55; }
.inline-disclaimer svg { flex-shrink: 0; color: var(--color-warning); margin-top: 2px; }

/* Safety list */
.safety-list { list-style: none; margin: 14px 0; }
.safety-item { display: flex; gap: 10px; padding: 8px 0; font-size: 15px; line-height: 1.55; }
.safety-item svg { flex-shrink: 0; margin-top: 4px; }
.safety-item.caution svg { color: var(--color-warning); }
.safety-item.info svg { color: var(--color-primary-light); }

/* Published research list */
.pub-list { list-style: none; }
.pub-item { padding: 16px 0; border-bottom: 1px solid var(--color-surface-alt); }
.pub-item:last-child { border-bottom: none; }
.pub-title { font-weight: 600; font-size: 15px; margin-bottom: 4px; line-height: 1.4; }
.pub-title a { color: var(--color-primary-light); }
.pub-title a:hover { color: var(--color-accent); text-decoration: underline; }
.pub-meta { font-size: 13px; color: var(--color-text-secondary); margin-bottom: 6px; }
.pub-meta .pub-journal { font-style: italic; }
.pub-summary { font-size: 14px; color: var(--color-text-secondary); line-height: 1.55; }

/* Related peptides grid */
.related-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin-top: 16px; }
.related-card { display: flex; align-items: center; gap: 14px; padding: 16px; background: var(--color-white); border: 1px solid var(--color-border); border-radius: var(--radius-md); text-decoration: none; color: inherit; transition: all 0.25s; }
.related-card:hover { border-color: var(--color-accent); box-shadow: var(--shadow-sm); color: inherit; }
.related-card-icon { width: 40px; height: 40px; background: var(--color-surface-alt); border-radius: 8px; display: flex; align-items: center; justify-content: center; flex-shrink: 0; font-size: 18px; }
.related-card h4 { font-size: 15px; font-weight: 600; margin-bottom: 1px; }
.related-card span { font-size: 12px; color: var(--color-text-secondary); }

/* Sourcing section - Elara card */
.source-card { background: var(--color-supplier-gold-light); border: 2px solid var(--color-supplier-gold); border-radius: var(--radius-lg); padding: 28px; margin-top: 20px; box-shadow: var(--shadow-gold); }
.source-badge { display: inline-flex; align-items: center; gap: 6px; font-size: 11px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.08em; color: var(--color-supplier-gold); margin-bottom: 12px; }
.source-card h3 { font-size: 20px; font-weight: 700; margin-bottom: 8px; }
.source-card > p { font-size: 15px; color: var(--color-text-secondary); margin-bottom: 18px; line-height: 1.6; }
.source-badges { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 18px; }
.source-trust { display: inline-flex; align-items: center; gap: 5px; padding: 6px 12px; background: var(--color-white); border: 1px solid var(--color-border); border-radius: 6px; font-size: 12px; font-weight: 600; }
.source-trust svg { color: var(--color-accent); }
.source-link { display: inline-flex; align-items: center; gap: 6px; padding: 10px 22px; background: var(--color-supplier-gold); color: var(--color-white); font-size: 15px; font-weight: 600; border-radius: var(--radius-sm); transition: all 0.2s; }
.source-link:hover { background: #C09A3A; color: var(--color-white); }
.source-disclosure { margin-top: 14px; font-size: 12px; color: var(--color-text-secondary); font-style: italic; }
.source-disclosure a { text-decoration: underline; }

/* ============================================================
   SIDEBAR
   ============================================================ */
.profile-sidebar { position: sticky; top: calc(var(--nav-height) + 24px); }
.sidebar-card { background: var(--color-white); border: 1px solid var(--color-border); border-radius: var(--radius-lg); padding: 22px; margin-bottom: 20px; }
.sidebar-card h4 { font-size: 13px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.08em; color: var(--color-text-secondary); margin-bottom: 14px; }
.sidebar-link { display: flex; align-items: center; gap: 10px; padding: 8px 0; font-size: 14px; font-weight: 500; color: var(--color-text-primary); border-bottom: 1px solid var(--color-surface-alt); }
.sidebar-link:last-child { border-bottom: none; }
.sidebar-link:hover { color: var(--color-accent); }
.sidebar-link svg { color: var(--color-text-secondary); flex-shrink: 0; }

/* Sidebar supplier mini card */
.sidebar-supplier { background: var(--color-supplier-gold-light); border: 1.5px solid var(--color-supplier-gold); border-radius: var(--radius-md); padding: 20px; margin-bottom: 20px; }
.sidebar-supplier h4 { font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.08em; color: var(--color-supplier-gold); margin-bottom: 10px; }
.sidebar-supplier p { font-size: 14px; color: var(--color-text-secondary); margin-bottom: 14px; line-height: 1.5; }
.sidebar-supplier-link { display: block; text-align: center; padding: 10px; background: var(--color-supplier-gold); color: var(--color-white); font-size: 14px; font-weight: 600; border-radius: var(--radius-sm); transition: background 0.2s; }
.sidebar-supplier-link:hover { background: #C09A3A; color: var(--color-white); }
.sidebar-supplier .source-disclosure { margin-top: 10px; }

/* Sidebar newsletter */
.sidebar-newsletter { background: var(--color-primary); border-radius: var(--radius-lg); padding: 22px; color: var(--color-white); }
.sidebar-newsletter h4 { color: var(--color-white); font-size: 15px; font-weight: 700; margin-bottom: 8px; text-transform: none; letter-spacing: normal; }
.sidebar-newsletter p { font-size: 13px; color: rgba(255,255,255,0.7); margin-bottom: 14px; }
.sidebar-newsletter input { width: 100%; padding: 10px 14px; font-family: var(--font-body); font-size: 14px; border: 1px solid rgba(255,255,255,0.2); border-radius: var(--radius-sm); background: rgba(255,255,255,0.08); color: var(--color-white); outline: none; margin-bottom: 8px; }
.sidebar-newsletter input::placeholder { color: rgba(255,255,255,0.4); }
.sidebar-newsletter button { width: 100%; padding: 10px; font-family: var(--font-body); font-size: 14px; font-weight: 600; background: var(--color-accent); color: var(--color-white); border: none; border-radius: var(--radius-sm); cursor: pointer; transition: background 0.2s; }
.sidebar-newsletter button:hover { background: var(--color-accent-dark); }

/* ============================================================
   FOOTER
   ============================================================ */
.prg-footer { background: var(--color-primary-dark); color: rgba(255,255,255,0.7); padding: 64px 0 0; }
.prg-footer-grid { display: grid; grid-template-columns: 1.4fr 1fr 1fr 1fr; gap: 48px; padding-bottom: 48px; border-bottom: 1px solid rgba(255,255,255,0.1); }
.prg-footer-brand p { font-size: 14px; line-height: 1.65; margin-top: 16px; color: rgba(255,255,255,0.55); }
.prg-footer-logo { font-size: 18px; font-weight: 800; color: var(--color-white); display: flex; align-items: center; gap: 10px; }
.prg-footer h4 { font-size: 13px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.1em; color: var(--color-white); margin-bottom: 20px; }
.prg-footer-links { list-style: none; }
.prg-footer-links li { margin-bottom: 10px; }
.prg-footer-links a { font-size: 14px; color: rgba(255,255,255,0.6); }
.prg-footer-links a:hover { color: var(--color-accent-light); }
.prg-footer-disclaimer { padding: 28px 0; border-bottom: 1px solid rgba(255,255,255,0.1); }
.prg-footer-disclaimer p { font-size: 13px; line-height: 1.7; color: rgba(255,255,255,0.45); max-width: 900px; }
.prg-footer-bottom { padding: 20px 0; display: flex; align-items: center; justify-content: space-between; font-size: 13px; color: rgba(255,255,255,0.4); }

/* ============================================================
   RESPONSIVE
   ============================================================ */
@media (max-width: 1100px) {
  .profile-layout { grid-template-columns: 1fr 280px; }
  .profile-toc { display: none; }
}
@media (max-width: 768px) {
  .prg-nav-links { display: none; position: absolute; top: var(--nav-height); left: 0; right: 0; background: var(--color-white); border-bottom: 1px solid var(--color-border); flex-direction: column; padding: 16px 24px; gap: 2px; box-shadow: var(--shadow-lg); }
  .prg-nav-links.active { display: flex; }
  .prg-nav-toggle { display: block; }
  .prg-page-header h1 { font-size: 28px; }
  .profile-layout { grid-template-columns: 1fr; gap: 24px; }
  .profile-sidebar { position: static; }
  .quick-facts { padding: 20px; }
  .qf-grid { grid-template-columns: 1fr; }
  .qf-item { padding: 10px 0 !important; border-right: none !important; padding-left: 0 !important; }
  .related-grid { grid-template-columns: 1fr; }
  .source-card { padding: 20px; }
  .prg-footer-grid { grid-template-columns: 1fr; gap: 32px; }
  .prg-footer-bottom { flex-direction: column; gap: 8px; text-align: center; }
}